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Parametric investigations of magnetic nanoparticles hyperthermia in ferrofluid using finite element analysis
International Journal of Thermal Sciences ( IF 4.9 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.ijthermalsci.2020.106604
Izaz Raouf 1 , Jaehun Lee 1 , Heung Soo Kim 1 , Min-Ho Kim 2
Affiliation  

Abstract Recently, magnetic nanoparticles (MNPs) based hyperthermia therapy has gained much attention due to its therapeutic potential in biomedical applications. This necessitates the development of numerical models that can reliably predict the temporal and spatial changes of temperature during the therapy. The objective of this study is to develop a comprehensive numerical model for quantitatively estimating temperature distribution in the ferrofluid system. The reliability of the numerical model was validated by comparative analysis of temperature distribution between experimental measurements and numerical analysis based on finite element method. Our analysis showed that appropriate incorporation of the heat effects of electromagnetic energy dissipation as well as thermal radiation from the ferrofluid system to the surrounding in the modeling resulted in the estimation of temperature distribution that is in close agreement with the experimental results. In summary, our developed numerical model is useful to evaluate the thermal behavior of the ferrofluid system during the process of magnetic fluid hyperthermia.

中文翻译:


使用有限元分析对铁磁流体中磁性纳米颗粒热热进行参数研究



摘要 近年来,基于磁性纳米粒子(MNP)的热疗因其在生物医学应用中的治疗潜力而受到广泛关注。这就需要开发能够可靠地预测治疗期间温度的时间和空间变化的数值模型。本研究的目的是开发一个综合数值模型,用于定量估计铁磁流体系统中的温度分布。通过实验测量温度分布与基于有限元方法的数值分析的对比分析,验证了数值模型的可靠性。我们的分析表明,在建模中适当纳入电磁能量耗散的热效应以及铁磁流体系统向周围环境的热辐射,导致温度分布的估计与实验结果非常一致。总之,我们开发的数值模型可用于评估磁流体热疗过程中铁磁流体系统的热行为。
更新日期:2021-01-01
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