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Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-06 , DOI: 10.1016/j.etap.2020.103488
Ademola Adetokunbo Oyagbemi 1 , Akinleye Stephen Akinrinde 1 , Olamide Elizabeth Adebiyi 1 , Theophilus Aghogho Jarikre 2 , Temidayo Olutayo Omobowale 3 , Olufunke Eunice Ola-Davies 1 , Adebowale Benard Saba 4 , Benjamin Obukowho Emikpe 3 , Adeolu Alex Adedapo 4
Affiliation  

Cobalt-induced cardiomyopathy and renal toxicity have been reported in workers in processing plants, hard metal industries, diamond polishing and manufacture of ceramics. This study was designed to investigate the influence of Luteolin supplementation on cobalt-induced cardiac and renal toxicity in rats. Exposure of rats to cobalt chloride (CoCl2) alone caused significant (p < 0.05) increases in cardiac and renal H2O2, malondialdehyde (MDA) and nitric oxide (NO), along with increased serum myeloperoxidase (MPO) activity. In addition, there were significant (p < 0.05) reductions in cardiac and renal glutathione peroxidase (GPx), glutathione S-transferase (GST) and reduced glutathione (GSH). CoCl2 induced higher immuno-staining of nuclear factor kappa beta (NF-κB) in the heart and kidneys, and the kidney injury molecule (Kim-1) in the kidneys. Treatment with Luteolin or Gallic acid produced significant reversal of the oxidative stress parameters with reductions in NF-κB and Kim-1 expressions, leading to suppression of histopathological lesions observed in the tissues.



中文翻译:

木犀草素补充通过抑制大鼠心脏和肾脏中的NF-кB/ Kim-1信号传导来改善钴诱导的氧化应激和炎症。

在加工厂,硬金属工业,金刚石抛光和陶瓷制造行业的工人中,已报道了钴引起的心肌病和肾毒性。本研究旨在研究补充木犀草素对钴诱导的大鼠心脏和肾脏毒性的影响。大鼠单独暴露于氯化钴(CoCl 2)会导致心脏和肾脏H 2 O 2,丙二醛(MDA)和一氧化氮(NO)显着(p <0.05)增加,以及血清髓过氧化物酶(MPO)活性增加。此外,心脏和肾脏的谷胱甘肽过氧化物酶(GPx),谷胱甘肽S-转移酶(GST)和谷胱甘肽(GSH)含量均明显降低(p <0.05)。氯化钴2诱导心脏和肾脏中核因子κB(NF-κB)和肾脏中肾脏损伤分子(Kim-1)的更高免疫染色。用木犀草素或没食子酸治疗可显着逆转氧化应激参数,同时降低NF-κB和Kim-1表达,从而抑制组织中观察到的组织病理学损害。

更新日期:2020-09-13
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