Background

Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed.

Aims

To map changes in the KP induced by infant CPB.

Methods

Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry.

Results

Infant CPB results in marked increase in proximal, but not distal metabolites of the KP.

Conclusions

Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.

中文翻译：

---

体外循环婴儿心脏手术后色氨酸代谢犬尿氨酸通路的激活：一项前瞻性队列研究。

背景

血清犬尿酸与婴儿体外循环 (CPB) 后的不良结局有关，但尚未对 CPB 后犬尿氨酸通路 (KP) 进行全面定位。

宗旨

绘制婴儿 CPB 引起的 KP 变化。

方法

通过液相色谱串联质谱法比较术后 48 小时血清 KP 代谢物的变化。

结果

婴儿 CPB 导致 KP 的近端而非远端代谢物显着增加。

结论

婴儿 CPB 导致循环 KP 代谢物的积累，这些代谢物具有重要的神经学和免疫学活性。因此，有必要在这些高危婴儿中进一步探索 KP。