Abstract

Attempted cyclodehydration of phenacyl mercaptoimidazole hydrobromide with acetic anhydride gave an abnormal product lacking the phenyl group. The molecular structure is confirmed using X-ray crystal structure studies. Phenacyl mercaptobenzimidazole hydrobromide behaved similarly. Analysis of crystal structure revealed an intermolecular S…Br chalcogen bonding interaction.

Graphic abstract

The cylization reaction of 2-phenacylmercaptoimidazole hydrobromide is carried out using acetic anhydride, afforded an unexpected imidazothiazole lacking a phenyl ring. The generality of the reaction is confirmed by a similar reaction which was carried out with phenacylmercaptobenzimidazole and yielded similar product

中文翻译：

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2-苯甲酰基巯基咪唑与乙酸酐的新型反应：咪唑并噻唑的形成，但没有苯基

摘要

尝试用乙酸酐对苯甲硫醇咪唑氢溴酸盐进行环脱水，得到缺少苯基的异常产物。使用X射线晶体结构研究证实了分子结构。苯甲酰基巯基苯并咪唑氢溴酸盐的行为相似。晶体结构分析表明分子间S…Br硫族元素键相互作用。

图形摘要

使用乙酸酐进行2-苯甲酰基巯基咪唑氢溴酸盐的环化反应，得到了意外的缺少苯环的咪唑并噻唑。该反应的普遍性通过用苯甲酰基巯基苯并咪唑进行的类似反应得到证实，得到了类似产物