Cell therapy is used to treat various diseases and to repair injuries. Cell delivery is a crucial process that delivers cells to target sites. Cells must be precisely delivered to a target site and the cells that are delivered must be localized to the target site to repair damaged tissue. For stem cell therapy, the most convenient method of cell delivery involves directly injecting cells into damaged tissue. Other strategies use carriers to transplant stem cells into damaged tissue. These are termed, stem cell delivery systems (SCDSs). Micro-needle arrays are minimally invasive transdermal delivery systems. The devices can pass through the stratum corneum barrier and deliver macromolecules into the skin. They can also access the microcirculation system in the skin. This study fabricates PMMA micro-needle using a two-stage micro-molding method. Cells are seeded on the micro-needle arrays and then transferred into the target tissue. Collagen hydrogel is used as a model biomimetic tissue. Cells are efficiently delivered to regions of interest, collagen hydrogel, by using this system. The delivery rate is about 83.2%. This demonstrates that micro-needle arrays allow very efficient delivery of cells.

细胞疗法用于治疗各种疾病和修复损伤。细胞递送是将细胞递送至目标位点的关键过程。细胞必须精确地输送到目标部位，并且输送的细胞必须定位到目标部位以修复受损的组织。对于干细胞治疗，最方便的细胞输送方法是将细胞直接注射到受损组织中。其他策略使用载体将干细胞移植到受损组织中。这些被称为干细胞输送系统（SCDS）。微针阵列是微创透皮给药系统。该装置可以穿过角质层屏障并将大分子输送到皮肤中。它们还可以进入皮肤的微循环系统。本研究采用两阶段微成型方法制造 PMMA 微针。将细胞接种在微针阵列上，然后转移到目标组织中。胶原水凝胶被用作仿生组织模型。通过使用该系统，细胞可以有效地输送到感兴趣的区域——胶原蛋白水凝胶。交货率约为83.2%。这表明微针阵列可以非常有效地输送细胞。