Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.

中文翻译：

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血管肉瘤：组织学、免疫组织化学和分子学洞察对鉴别诊断的影响。

血管肉瘤 (AS) 代表一组异质性的肿瘤，具有不同的临床表现。AS 与其他肉瘤有重要的形态学和免疫组织化学重叠，因此鉴别诊断具有挑战性，尤其是在低分化肿瘤中。尽管分子研究提供了重要线索，尤其是在与其他血管肿瘤的鉴别诊断中，但彻底的苏木精和伊红分析仍然是 AS 诊断的重要工具。在这篇综述中，我们讨论了病理学和分子学的见解，重点是对皮肤、乳腺、软组织和内脏 AS 的鉴别诊断的影响。