The liver is the target of several infectious, inflammatory, and neoplastic diseases, which affect hundreds of millions of people worldwide and cause an estimated death toll of more than 2 million people each year. Dysregulation of T cell responses has been implicated in the pathogenesis of these diseases; hence, it is critically important to understand the function and fate of T cells in the liver. Here, we provide an overview of the current knowledge on liver immune surveillance by conventional and invariant T cells and explore the complex cross-talk between immune cell subsets that determines the balance between hepatic immunity and tolerance.

中文翻译：

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T细胞对肝脏的免疫监测。

肝脏是多种传染性、炎症性和肿瘤性疾病的靶点，这些疾病影响着全世界数亿人，估计每年造成超过 200 万人死亡。T 细胞反应的失调与这些疾病的发病机制有关。因此，了解肝脏中 T 细胞的功能和命运至关重要。在这里，我们概述了当前关于常规和不变 T 细胞进行肝脏免疫监视的知识，并探讨了决定肝脏免疫和耐受性平衡的免疫细胞亚群之间复杂的串扰。