Copper-catalyzed carbonylative synthesis of pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters,Organic Chemistry Frontiers

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Copper-catalyzed carbonylative synthesis of pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-09-04 , DOI: 10.1039/d0qo00999g
Youcan Zhang _{1,

2,

3} , Han-Jun Ai _{1,

2,

3} , Xiao-Feng Wu _{1,

2,

3,

4,

5}

Affiliation

A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters and amines has been described. A range of readily available amines were examined, including primary, secondary, and heterocycle amines, giving over 60 examples of targeted N-heterocycle substituted amides with broad functional group tolerance, good chemical selectivity and moderate to excellent yields.

中文翻译：

铜催化由γ，δ-不饱和芳族肟酯羰基合成吡咯烷酰胺

描述了一种低成本的铜催化羰基化环化的新方法，该方法可从γ，δ-不饱和芳族肟酯和胺制备含吡咯烷的酰胺。检查了一系列容易获得的胺，包括伯，仲和杂环胺，给出了60多个目标N-杂环取代的酰胺实例，它们具有宽泛的官能团耐受性，良好的化学选择性以及中等至极好的收率。

更新日期：2020-09-30

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