This paper investigated the dual-role of cystamine as a surface modification linker and stimuli-responsive material, and simplify redox-responsive drug delivery system synthesis. ZIF-8 is used as the drug delivery vehicle (due to its exceptional biocompatibility), cystamine is used as the linker and redox-sensitive material, and paclitaxel (PTX) is selected as the anti-tumor drug. Redox-responsive paclitaxel drug delivery platform based on metal-organic frameworks (MOFs) was synthesized by using ZIF-8 as the drug delivery vehicle, and cystamine as the linker and redox-sensitive material. The morphology of ZIF-8 was determined by the Transmitting Electron Microscope (TEM), and the crystal structure was determined by x-ray diffraction (XRD). The surface modification of ZIF-8 was studied by the Fourier-transform infrared (FT-IR) spectroscopy. The Brunauer–Emmett–Teller (BET) study indicated that surface modification has little impact on the specific surface area and pore size distr...

中文翻译：

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使用金属有机框架（ZIF-8）轻松合成氧化还原反应性紫杉醇药物释放平台以治疗胃癌

本文研究了胱胺作为表面修饰连接物和刺激反应物质的双重作用，并简化了氧化还原反应药物递送系统的合成。ZIF-8被用作药物输送载体（由于其出色的生物相容性），胱胺被用作连接剂和氧化还原敏感材料，紫杉醇（PTX）被选作抗肿瘤药物。以ZIF-8为药物传递载体，以胱胺为连接剂和氧化还原敏感性物质，合成了基于金属有机骨架（MOFs）的氧化还原反应型紫杉醇药物传递平台。通过透射电子显微镜（TEM）确定ZIF-8的形态，并通过X射线衍射（XRD）确定晶体结构。ZIF-8的表面改性通过傅立叶变换红外（FT-IR）光谱进行了研究。