Blends of PLLA and PCL yielded by solvent casting usually exhibit phase separation and crystallization behavior which have a strong impact on their suitability for certain biomedical applications such as degradable coatings or drug carriers. Therefore, it is important to understand the underlying mechanisms. In this study, high-molecular biodegradable semi-crystalline poly(L-lactide) (PLLA) (M w = 320 kDa) was blended with low-molecular biodegradable semi-crystalline poly( ε -caprolactone) (PCL) (M w = 40 kDa) in various combinations (10, 50 and 90 wt.% PCL) by solvent casting. The yielded blends were subjected to annealing at 40 °C, 80 °C and 200 °C and cooled down slowly to maintain thermodynamic equilibrium. Scanning electron microscopy, atomic force microscopy, Raman images and differential scanning calorimetry were used to investigate the structure, morphology and thermal properties of the solvent cast PLLA/PCL blends. It was shown that the physico-...

中文翻译：

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从溶剂浇铸工艺获得的高分子PLLA与低分子PCL混合的理化和相分离特性

通过溶剂流延产生的PLLA和PCL的共混物​​通常表现出相分离和结晶行为，这对它们对某些生物医学应用如可降解涂层或药物载体的适用性具有强烈影响。因此，了解底层机制很重要。在这项研究中，将高分子可生物降解的半结晶聚（L-丙交酯）（Mw = 320 kDa）与低分子生物可降解的半结晶聚（ε-己内酯）（PCL）（M w =通过溶剂浇铸，以各种组合（10％，50％和90％（重量）PCL）的方式加入40 kDa）。将得到的共混物在40℃，80℃和200℃下进行退火，并缓慢冷却以保持热力学平衡。扫描电子显微镜，原子力显微镜，拉曼图像和差示扫描量热法用于研究溶剂浇铸的PLLA / PCL共混物的结构，形态和热性能。结果表明，物理...