We report on a novel rapid prototyping approach for the manufacturing of highly individualized lab-on-chip (LoC) cartridges from generic polymer parts by laser micromachining and laser welding. The approach allows an immediate implementation of microfluidic networks, components, and functionalities into an existing LoC platform without the need for an expensive and time-consuming fabrication of production tools like molds or masks. We comprehensively describe the individual process steps of the rapid prototyping procedure including a wet-chemical treatment for an easy and effective surface polishing of laser micromachined polymer parts. For laying out, we introduce a generalized diagrammatic description of microfluidic functional units in order to design application-specific cartridges for molecular diagnostic workflows. We demonstrate the usability of our prototyped cartridges by performing microfluidic experiments within. Due to the use of generic polymer parts, our rapid prot...

中文翻译：

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在一天之内从CAD到微流控芯片：使用通用聚合物零件对芯片实验室芯片盒进行快速原型制作

我们报告了一种新颖的快速原型制作方法，该方法用于通过激光微加工和激光焊接从通用聚合物零件制造高度个性化的芯片实验室（LoC）墨盒。该方法允许将微流体网络，组件和功能立即实施到现有的LoC平台中，而无需昂贵且费时的制造工具（如模具或掩模）的制造。我们全面描述了快速成型过程的各个处理步骤，包括湿化学处理，以对激光微加工聚合物零件进行简单有效的表面抛光。为了进行布局，我们介绍了微流体功能单元的一般示意图，以设计用于分子诊断工作流程的专用盒。我们通过在其中进行微流体实验证明了原型墨盒的可用性。由于使用了通用的聚合物零件，我们的快速保护产品...