This research article presents the preparation and characterization of monolithic columns with incorporated bare fumed silica nanoparticles (FSNPs) and cyano-modified FNSPs (CN-FSNPs) and their subsequent use in hydrophilic interaction liquid chromatography (HILIC) of neutral, polar, and low molecular weight solutes. The monolithic support was based on the in situ polymerization of glyceryl monomethacrylate (GMM) and ethylene glycol dimethacrylate (EDMA) yielding the poly(GMM-co-EDMA) monolith for the incorporation of bare FNSPs and of CN-FSNPs. The poly(GMM-co-EDMA) functioned as a “true support” for bare FSNPs and CN-FSNPs “stationary phases” as manifested by bare FSNPs and CN-FSNPs being the major contributors to solute retention and column selectivity. Overall, the prepared bare FSNPs and CN-FSNPs stationary phases proved useful in HILIC of small polar solutes including dimethylformamide, formamide, thiourea, nucleobases, nucleosides, organic acids, food additives, vitamins, and biological amines.

中文翻译：

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用于亲水相互作用液相色谱的含有裸露和氰基改性气相二氧化硅纳米粒子的有机聚合物整体柱

这篇研究文章介绍了掺入了裸气相二氧化硅纳米粒子 (FSNPs) 和氰基改性 FNSPs (CN-FSNPs) 的整体柱的制备和表征，以及它们随后在中性、极性和低分子的亲水相互作用液相色谱 (HILIC) 中的应用。重量溶质。整体支撑基于单甲基丙烯酸甘油酯 (GMM) 和乙二醇二甲基丙烯酸酯 (EDMA) 的原位聚合，产生聚 (GMM-co-EDMA) 整体，用于掺入裸 FNSP 和 CN-FSNP。聚 (GMM-co-EDMA) 充当裸 FSNP 和 CN-FSNP“固定相”的“真正支持”，如裸 FSNP 和 CN-FSNP 是溶质保留和色谱柱选择性的主要贡献者。全面的，