As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. We conducted a prospective study to compare reinforced education using Wechat with care as usual from February to December 2019. Patients in the reinforced education group received reinforced education via Wechat, while those in the control group received care as usual. Effect measurements for both groups are carried out with questionnaires at the baseline and 3 days later. Questionnaires include pain intensity (NRS), treatment-related adverse events, cancer-related quality of life (QOL), sleep (PSQI), satisfaction, anxiety (GAD-7) and depression (PHQ-9). Number of patients whose NRS reduced to less than three points in 24 h was the primary outcomes. Secondary outcomes included treatment-related adverse events, cancer-related quality of life, sleep, satisfaction, anxiety and depression. Although there was no significant difference regarding pain intensity (NRS) between the two groups at 72 h, the rate of NRS that reduced to less than three points in 24 h was significantly higher in the Wechat group than in the control group. Patients’ satisfaction was significantly higher in the Wechat group than in the control group. There was no significant difference between the two groups regarding the other findings at 72 h, including pain intensity (NRS), cancer-related quality of life (QOL), anxiety (GAD-7), depression (PHQ-9), and sleep (PSQI). However, no significant difference was found between the two groups for constipation, nausea, vomiting, dizziness, somnolence, pruritus, loss of consciousness, and death. Our results indicated that receiving instructions delivered by Wechat resulted an increased number of patients with good pain control and better satisfaction. The study provided insight into the effectiveness of the reinforced education using a Wechat app delivered by a doctor to outpatients in the titration treatment of cancer-related pain. This study was registered at chictr.org (Registration number: ChiCTR1900021150 , Date of Registration: January 30, 2019).

中文翻译：

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基于微信应用程序的强化教育提高了阿片类药物滴定治疗门诊癌症相关疼痛的质量：一项随机对照研究。

由于疼痛沟通不足导致难以优化门诊病人的病情，我们调查了使用微信应用强化教育对门诊患者癌症相关性疼痛的阿片类药物滴定治疗的效果。我们进行了一项前瞻性研究，以比较自2019年2月至2019年12月照常使用微信的强化教育。强化教育组的患者通过微信接受强化教育，而对照组的患者照常接受护理。在基线和3天后用问卷调查两组的效果。调查问卷包括疼痛强度（NRS），与治疗相关的不良事件，与癌症相关的生活质量（QOL），睡眠（PSQI），满意度，焦虑症（GAD-7）和抑郁症（PHQ-9）。主要结果是在24小时内NRS降至3分以下的患者人数。次要结果包括与治疗有关的不良事件，与癌症有关的生活质量，睡眠，满意度，焦虑和抑郁。尽管两组在72小时时的疼痛强度（NRS）没有显着差异，但微信组中24小时内NRS降至3分以下的比率明显高于对照组。微信组的患者满意度明显高于对照组。两组在72小时时的其他发现之间没有显着差异，包括疼痛强度（NRS），癌症相关的生活质量（QOL），焦虑症（GAD-7），抑郁症（PHQ-9）和睡眠（PSQI）。然而，便秘，恶心，呕吐，头晕，嗜睡，瘙痒，意识丧失和死亡在两组之间没有发现显着差异。我们的结果表明，接受微信提供的指导后，疼痛控制和满意度更高的患者人数有所增加。该研究通过医生向门诊病人提供的微信应用微信应用程序，在癌症相关性疼痛的滴定治疗中提供了强化教育效果的见解。该研究已在chictr.org上注册（注册号：ChiCTR1900021150，注册日期：2019年1月30日）。我们的结果表明，接受微信提供的指导后，疼痛控制和满意度更高的患者人数有所增加。该研究通过医生向门诊病人提供的微信应用微信应用程序在癌症相关性疼痛的滴定治疗中提供了强化教育效果的见解。该研究已在chictr.org上进行了注册（注册号：ChiCTR1900021150，注册日期：2019年1月30日）。我们的结果表明，接受微信提供的指导后，疼痛控制和满意度更高的患者人数有所增加。该研究通过医生向门诊病人提供的微信应用微信应用程序在癌症相关性疼痛的滴定治疗中提供了强化教育效果的见解。该研究已在chictr.org上注册（注册号：ChiCTR1900021150，注册日期：2019年1月30日）。