Heterogeneously catalysed synthesis of primary amines by direct amination of alcohols with ammonia has long been an elusive goal. In contrast to reported Ru-based catalytic systems, we report that Ru–MgO/TiO₂ acts as an effective heterogeneous catalyst for the direct amination of a variety of alcohols to primary amines at low temperatures of ca. 100 °C without the introduction of H₂ gas. The present system could be applied to a variety of alcohols and provides an efficient synthetic route for 2,5-bis(aminomethyl)furan (BAMF), an attention-getting biomonomer. The high catalytic performance can be rationalized by the reactivity tuning of Ru–H species using MgO. Spectroscopic measurements suggest that MgO enhances the reactivity of hydride species by electron donation from MgO to Ru.

中文翻译：

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氢化钌对多相钌催化剂上醇直接胺化对伯胺合成的影响

通过醇与氨的直接胺化而异质催化合成伯胺一直是一个遥不可及的目标。与报道的基于Ru的催化体系相反，我们报道Ru–MgO / TiO ₂是一种有效的非均相催化剂，可在约20 ℃的低温下将多种醇直接胺化成伯胺。100°C，不引入H ₂加油站。本系统可应用于多种醇，并为引起人们关注的生物单体2,5-双（氨基甲基）呋喃（BAMF）提供了有效的合成途径。可以通过使用MgO调节Ru–H物种的反应性来合理化高催化性能。光谱测量表明，MgO通过从MgO向Ru供电子而增强了氢化物物种的反应性。