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MicroRNAs in Lung Cancer Oncogenesis and Tumor Suppression: how it can improve the clinical practice?
Current Genomics ( IF 1.8 ) Pub Date : 2020-09-04 , DOI: 10.2174/1389202921999200630144712
Daniel Humberto Pozza 1 , Ramon Andrade De Mello 1 , Raphael L C Araujo 1 , Vamsidhar Velcheti 1
Affiliation  

Background Lung cancer (LC) development is a process that depends on genetic mutations. The DNA methylation, an important epigenetic modification, is associated with the expression of non-coding RNAs, such as microRNAs. MicroRNAs are particularly essential for cell physiology, since they play a critical role in tumor suppressor gene activity. Furthermore, epigenetic disruptions are the primary event in cell modification, being related to tumorigenesis. In this context, microRNAs can be a useful tool in the LC suppression, consequently improving prognosis and predicting treatment. Conclusion This manuscript reviews the main microRNAs involved in LC and its potential clinical applications to improve outcomes, such as survival and better quality of life.

中文翻译:

肺癌肿瘤发生和肿瘤抑制中的微小RNA:它如何改善临床实践?

背景 肺癌 (LC) 的发展是一个依赖于基因突变的过程。DNA甲基化是一种重要的表观遗传修饰,与非编码RNA(如microRNA)的表达有关。MicroRNAs 对于细胞生理学尤为重要,因为它们在肿瘤抑制基因活性中发挥着关键作用。此外,表观遗传破坏是细胞修饰的主要事件,与肿瘤发生有关。在这种情况下,microRNA 可以成为抑制 LC 的有用工具,从而改善预后和预测治疗。结论 本手稿回顾了 LC 中涉及的主要 microRNA 及其潜在的临床应用,以改善预后,例如生存率和更好的生活质量。
更新日期:2020-09-04
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