Drug administration to experimental rodents is often invasive and stressful, thus reducing animal welfare and potentially confounding experimental results. Methods of oral drug delivery in which rodents cooperate voluntarily minimize stress, pain and morbidity. We herein describe a method for oral administration through voluntary intake of strawberry jam, developed for C57BL/6J mice. During a 3-day habituation period, animals were placed in individual cages once daily and presented with a drop of jam. Five days later, the jam was again offered with admixed drug. Mice ingested it in less than 5 min, with latency times below 1 min, confirming the suitability of the administration method.

对实验啮齿动物的药物管理通常是侵入性的和有压力的，从而降低动物福利并可能混淆实验结果。啮齿动物自愿合作的口服给药方法可以最大限度地减少压力、疼痛和发病率。我们在此描述了一种通过自愿摄入草莓酱进行口服给药的方法，该方法是为 C57BL/6J 小鼠开发的。在为期 3 天的适应期中，每天一次将动物放入单独的笼子中，并提供一滴果酱。五天后，果酱再次与混合药物一起提供。小鼠在不到 5 分钟内摄入它，潜伏时间低于 1 分钟，证实了给药方法的适用性。