Acute aortic dissection (AD) is one of the most severe and highly mortality vascular disease. Its actual prevalence may be seriously underestimated. We studied different expression genes to understand gene profile change between acute AD and nondiseased individuals, and then discover potential biomarkers and therapeutic targets of acute AD. In our study, acute AD differentially expressed mRNAs and miRNAs were identified through bioinformatics analysis on Gene Expression Omnibus data sets GSE52093, GSE98770, and GSE92427. Then, comprehensive target prediction and network analysis methods were used to evaluate protein–protein interaction networks and to identify Gene Ontology terms for differentially expressed mRNAs. Differentially expressed mRNAs-miRNAs involved in acute AD were assessed as well. Finally, the quantitative real-time PCR and in vitro experiment was used to validate the results. We found Integral Membrane Protein 2C (ITM2C) was low expressed and miR-107-5p was highly expressed in acute AD tissues. Meanwhile, overexpression miR-107-5p promoted the cell proliferation and inhibited the cell apoptosis in RASMC cells. miR-107-5p inhibited the progression of acute AD through targeted ITM2C.

中文翻译：

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miR-107作为急性主动脉夹层的潜在生物标志物和细胞因子的作用。

急性主动脉夹层（AD）是最严重，死亡率最高的血管疾病之一。它的实际患病率可能会被严重低估。我们研究了不同的表达基因，以了解急性AD和未患病个体之间的基因谱变化，然后发现急性AD的潜在生物标志物和治疗靶标。在我们的研究中，通过对Gene Expression Omnibus数据集GSE52093，GSE98770和GSE92427进行生物信息学分析，鉴定了急性AD差异表达的mRNA和miRNA。然后，使用全面的目标预测和网络分析方法评估蛋白质之间的相互作用网络，并鉴定差异表达的mRNA的基因本体学术语。还评估了与急性AD有关的差异表达的mRNA-miRNA。最后，实时定量PCR和体外实验用于验证结果。我们发现整合膜蛋白2C（ITM2C）在急性AD组织中低表达，而miR-107-5p高表达。同时，miR-107-5p的过度表达促进了RASMC细胞的增殖并抑制了细胞凋亡。miR-107-5p通过靶向ITM2C抑制急性AD的进展。