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Construction of Benzothiophene or Benzothiopheno[2,3-e]azepinedione Derivatives via Three-Component Domino or One-Pot Sequences.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.joc.0c01505 Qingsong Deng 1 , Aimin Yu 1 , Jie Zhou 2 , Qin Cao 1 , Xiangtai Meng 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.joc.0c01505 Qingsong Deng 1 , Aimin Yu 1 , Jie Zhou 2 , Qin Cao 1 , Xiangtai Meng 1
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An efficient three-component domino or one-pot strategy has been developed for the synthesis of medicinally important benzothiophene and benzothiopheno[2,3-e]azepinedione derivatives for the first time. Amine-promoted selective cleavage of C–S bond of thioisatin is the key step in this process. The reported methodology benefits from environmentally friendly solvent (H2O), wide substrate scope, good functional group tolerance, and high reaction yields.
中文翻译：
通过三组分多米诺或一锅序列构建苯并噻吩或苯并噻吩[2,3-e]氮杂二酮衍生物。
首次开发了一种有效的三组分多米诺骨牌或一锅法，用于合成具有医学重要性的苯并噻吩和苯并噻吩[2,3- e ]氮杂二酮衍生物。胺促进的硫代丝氨酸的C–S键选择性裂解是该过程的关键步骤。报告的方法得益于环保溶剂（H 2 O），较宽的底物范围，良好的官能团耐受性和较高的反应产率。
更新日期：2020-10-02
中文翻译：
通过三组分多米诺或一锅序列构建苯并噻吩或苯并噻吩[2,3-e]氮杂二酮衍生物。
首次开发了一种有效的三组分多米诺骨牌或一锅法，用于合成具有医学重要性的苯并噻吩和苯并噻吩[2,3- e ]氮杂二酮衍生物。胺促进的硫代丝氨酸的C–S键选择性裂解是该过程的关键步骤。报告的方法得益于环保溶剂（H 2 O），较宽的底物范围，良好的官能团耐受性和较高的反应产率。
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