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Iridium-Catalyzed C-Alkylation of Methyl Group on N-Heteroaromatic Compounds using Alcohols.
Organic Letters ( IF 4.9 ) Pub Date : 2020-09-04 , DOI: 10.1021/acs.orglett.0c02635 Mitsuki Onoda 1 , Ken-Ichi Fujita 1
Organic Letters ( IF 4.9 ) Pub Date : 2020-09-04 , DOI: 10.1021/acs.orglett.0c02635 Mitsuki Onoda 1 , Ken-Ichi Fujita 1
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In this study, we developed a catalytic system for the C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl2]2 (Cp*: η5-pentamethylcyclopentadienyl) combined with potassium t-butoxide and 18-crown-6-ether as the catalyst precursor.
中文翻译:
使用醇,铱在N-杂芳族化合物上催化甲基的C-烷基化。
在这项研究中,我们开发了一种催化体系,用于使用N [Cp * IrCl 2 ] 2(Cp *:η5-五甲基环戊二烯基)与叔丁醇钾和18-冠-6-醚组合作为催化剂前体。
更新日期:2020-09-20
中文翻译:
使用醇,铱在N-杂芳族化合物上催化甲基的C-烷基化。
在这项研究中,我们开发了一种催化体系,用于使用N [Cp * IrCl 2 ] 2(Cp *:η5-五甲基环戊二烯基)与叔丁醇钾和18-冠-6-醚组合作为催化剂前体。