A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon–carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.

中文翻译：

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钯催化的[5 + 2]乙烯基碳酸乙烯酯与巴比妥酸酯衍生的烯烃。

已经开发出钯/ XantPhos催化的VEC [5 + 2]与带有电子碳原子-碳双键的缺电子烯烃进行环化，以提供螺巴比妥酸酯-四氢氧杂环丁烷。这项研究提供了生物学上有趣的螺巴比妥酸酯-四氢氧杂环丁烷的便利组装。还显示了反应产物的容易的可扩展性和通用的可转化性。