Based on the role of oxidative stress in the pathophysiological mechanisms of sepsis and the importance of PCT as a clinically applicable biomarker for early detection of inflammatory response initiation, we aimed this study at examining the correlation between PCT levels and oxidative stress parameters (prooxidants and antioxidants) in patients with sepsis. This study was designed as a case-series prospective clinical study which involved 103 critically ill patients and 17 healthy participants with diagnosis of sepsis/septic shock (over 18 years of age, both gender) admitted to the Intensive Care Unit (ICU) of Valjevo General Hospital in Serbia. All subjects were divided into patients who were operated on/underwent surgery before sampling and have sepsis (), patients who were operated on/underwent surgery before sampling and have septic shock (), patients who were not operated on/did not undergo surgery before sampling and have sepsis (), patients who were not operated on/did not undergo surgery before sampling and have septic shock (), and participants who are healthy (). PCT has confirmed a positive correlation with prooxidants and type of critical illness, and performing surgical intervention diminished oxidative stress in patients with septic shock. Prognosis in critically ill patients was strongly associated with PCT levels but not with nonspecifically C-reactive protein.

中文翻译：

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脓毒症患者氧化还原状态与降钙素原和C反应蛋白的相关性。

基于氧化应激在败血症的病理生理机制中的作用以及PCT作为早期检测炎症反应启动的临床适用生物标志物的重要性，我们旨在研究PCT水平与氧化应激参数（促氧化剂和抗氧化剂）之间的相关性）败血症患者。该研究设计为病例系列前瞻性临床研究，涉及103名重症患者和17名健康参与者，诊断为败血症/败血性休克（年龄均超过18岁，男女均适用），接受了Valjevo重症监护病房（ICU）的治疗塞尔维亚的综合医院。将所有受试者分为样本前接受过外科手术/手术且患有败血症的患者（），在取样前进行过手术/进行过手术且患有败血性休克的患者（），未进行手术/未做手术的患者在取样前未进行手术且患有败血症（），未进行手术/未做手术的患者在取样前未进行过手术且患有败血性休克（）以及健康的参与者（）。PCT已证实与促氧化剂和危重疾病类型呈正相关，并且进行外科手术可减少败血性休克患者的氧化应激。重症患者的预后与PCT水平密切相关，但与非特异性C反应蛋白无关。