Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation,Chemistry of Materials

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Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
Chemistry of Materials ( IF 7.2 ) Pub Date : 2020-09-04 , DOI: 10.1021/acs.chemmater.0c02911
Tomáš Sedlačík _{1,

2} , Takayuki Nonoyama _{1,

2} , Honglei Guo _{1,

2} , Ryuji Kiyama ₃ , Tasuku Nakajima _{1,

2,

4} , Yoshihiro Takeda ₅ , Takayuki Kurokawa _{1,

2} , Jian Ping Gong _{1,

2,

4}

Affiliation

Supermacroporous hydrogels, possessing a spongelike structure and permeability, have drawn significant attention for their bioengineering and biomedical applications. However, their mechanical weakness due to the low-density structure is one of their biggest limitations. This work reports a multistep cryogelation technique, which does not require special equipment, for preparing tough supermacroporous hydrogels on the basis of the double-network (DN) strategy. The produced supermacroporous DN gels possess interconnected pores with pore sizes of 50–230 μm. They also show a compressive modulus of up to ∼100 kPa, which is 2–4 times higher than that of the corresponding supermacroporous single-network (SN) gels, and a compressive strength of up to 1 MPa at 80% compression. The supermacroporous DN cryogels are also stretchable with a work of extension of up to 38 kJ m^–3, which is 1–2 orders larger than that of the SN cryogels. Their high stiffness and stretchability distinguish them from other types of cryogels. Supermacroporous triple-network (TN) gels and DN gels composed of different polymer combinations are also prepared. The technique presented herein is suitable for preparing supermacroporous DN gels from various polymers; hence, it is promising in meeting bioengineering and biomedical demands.

中文翻译：

通过反复低温凝胶化制备坚韧的双网和三网超巨水凝胶

具有海绵状结构和渗透性的超大尺寸水凝胶因其生物工程和生物医学应用而引起了极大的关注。但是，由于低密度结构而导致的机械强度不足是其最大的局限之一。这项工作报告了一种多步冷冻凝胶技术，该技术不需要特殊设备，即可在双网络（DN）策略的基础上制备坚韧的超大尺寸水凝胶。所生产的超大分子DN凝胶具有相互连接的孔，孔径为50–230μm。它们还显示出高达〜100 kPa的压缩模量，是相应的超大单层网状（SN）凝胶的2-4倍，在80％压缩时的压缩强度高达1 MPa。^–3，比SN冷冻凝胶大1–2个数量级。它们的高刚度和可拉伸性使其区别于其他类型的冰晶。还制备了由不同聚合物组合组成的超巨三元网络（TN）凝胶和DN凝胶。本文介绍的技术适用于由各种聚合物制备超大尺寸DN凝胶；因此，在满足生物工程和生物医学需求方面很有希望。

更新日期：2020-10-13

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