Abstract

DELLA proteins are the negative regulators of the gibberellin (GA) signaling pathway. GAs have a pervasive effect on plant physiology, influencing processes that span the entire life cycle of the plant. All the information encoded by GAs, either environmental or developmental in origin, is canalized through DELLAs, which modulate the activity of many transcription factors and transcriptional regulators. GAs unlock the signaling pathway by triggering DELLA polyubiquitination and degradation by the 26S proteasome. Recent reports indicate, however, that there are other pathways that trigger DELLA polyubiquitination and degradation independently of GAs. Moreover, results gathered during recent years indicate that other post-translational modifications (PTMs), namely phosphorylation, SUMOylation and glycosylation, modulate DELLA function. The convergence of several PTMs in DELLA therefore highlights the strict regulation to which these proteins are subject. In this review, we summarize these discoveries and discuss DELLA PTMs from an evolutionary perspective and examine the possibilities these and other post-translational regulations offer to improve DELLA-dependent agronomic traits.

中文翻译：

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通过翻译后修饰调节 DELLA 蛋白。

摘要

DELLA 蛋白是赤霉素 (GA) 信号通路的负调节因子。GA 对植物生理学具有普遍影响，影响跨越植物整个生命周期的过程。GA 编码的所有信息，无论是环境信息还是发育信息，都通过 DELLA 进行传导，DELLA 调节许多转录因子和转录调节因子的活性。GA 通过触发 DELLA 多泛素化和 26S 蛋白酶体降解来解锁信号通路。然而，最近的报告表明，还有其他途径可以独立于 GA 触发 DELLA 多泛素化和降解。此外，近年来收集的结果表明其他翻译后修饰（PTM），即磷酸化、SUMO化和糖基化，调节DELLA功能。因此，DELLA 中多个 PTM 的融合凸显了这些蛋白质受到的严格调控。在这篇综述中，我们总结了这些发现，并从进化的角度讨论了 DELLA PTM，并研究了这些和其他翻译后调控为改善 DELLA 依赖性农艺性状提供的可能性。