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Inhibitors of α-Synuclein Fibrillation and Oligomer Toxicity in Rosa damascena: The All-Pervading Powers of Flavonoids and Phenolic Glycosides.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-04 , DOI: 10.1021/acschemneuro.0c00528 Hoda Eskandari 1 , Mustafa Ghanadian 2 , Clarice Noleto-Dias 3 , Charlotte Lomax 3 , Ahmed Tawfike 3 , Gunna Christiansen 4 , Duncan S Sutherland 1 , Jane L Ward 3 , Hossein Mohammad-Beigi 1 , Daniel E Otzen 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-04 , DOI: 10.1021/acschemneuro.0c00528 Hoda Eskandari 1 , Mustafa Ghanadian 2 , Clarice Noleto-Dias 3 , Charlotte Lomax 3 , Ahmed Tawfike 3 , Gunna Christiansen 4 , Duncan S Sutherland 1 , Jane L Ward 3 , Hossein Mohammad-Beigi 1 , Daniel E Otzen 1
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There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-synuclein (α-Syn), whose aggregation is key to the development of Parkinson’s disease (PD). Rosa damascena is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence of α-Syn fibrillation inhibitors in R. damascena extract. Different HPLC fractions of the extract were assessed in α-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC–MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin which were subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits of R. damascena extract to combat PD at the population level.
中文翻译：
玫瑰蔷薇中α-突触核蛋白纤颤抑制剂和低聚物毒性：类黄酮和酚类糖苷的无处不在。
人们正在寻找能够抑制α-突触核蛋白（α-Syn）的低聚和原纤化的天然化合物，α-突触核蛋白的聚集是帕金森氏病（PD）发生的关键。罗莎（Rosa damascena）是一种药用草药，广泛用于中东食品，仪式和香水中。已知该草药含有许多不同的多酚。在这里，我们研究了大马士革念珠菌中α-Syn纤颤抑制剂的存在。提取。提取物的不同HPLC馏分在α-Syn原纤化和毒性试验中进行评估。根据MTT和LDH分析，活性最高的馏分导致形成更多的α-Syn低聚物，但对SH-SY5Y细胞的毒性较小。LC-MS分析鉴定出没食子酸，山emp酚3-葡萄糖苷，山emp酚-3-O-β-芸香糖苷和槲皮素，它们随后被证明是强α-Syn纤颤抑制剂。我们的结果突出了大马士革提取物在人口水平上对抗PD的益处。
更新日期：2020-10-07
中文翻译：
玫瑰蔷薇中α-突触核蛋白纤颤抑制剂和低聚物毒性：类黄酮和酚类糖苷的无处不在。
人们正在寻找能够抑制α-突触核蛋白（α-Syn）的低聚和原纤化的天然化合物，α-突触核蛋白的聚集是帕金森氏病（PD）发生的关键。罗莎（Rosa damascena）是一种药用草药，广泛用于中东食品，仪式和香水中。已知该草药含有许多不同的多酚。在这里，我们研究了大马士革念珠菌中α-Syn纤颤抑制剂的存在。提取。提取物的不同HPLC馏分在α-Syn原纤化和毒性试验中进行评估。根据MTT和LDH分析，活性最高的馏分导致形成更多的α-Syn低聚物，但对SH-SY5Y细胞的毒性较小。LC-MS分析鉴定出没食子酸，山emp酚3-葡萄糖苷，山emp酚-3-O-β-芸香糖苷和槲皮素，它们随后被证明是强α-Syn纤颤抑制剂。我们的结果突出了大马士革提取物在人口水平上对抗PD的益处。
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