Versatile Nanoplatform Loaded with Doxorubicin and Graphene Quantum Dots/Methylene Blue for Drug Delivery and Chemophotothermal/Photodynamic Synergetic Cancer Therapy,ACS Applied Bio Materials

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Versatile Nanoplatform Loaded with Doxorubicin and Graphene Quantum Dots/Methylene Blue for Drug Delivery and Chemophotothermal/Photodynamic Synergetic Cancer Therapy
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-09-04 , DOI: 10.1021/acsabm.0c00942
Junlong Liang ₁ , Jianjun Liu ₁ , Xiaokang Jin ₁ , Shuting Yao ₁ , Biling Chen ₁ , Qianwei Huang ₁ , Jinhua Hu ₁ , Junmin Wan ₂ , Zhiwen Hu ₂ , Bing Wang ₁

Affiliation

A versatile platform for nanodrug delivery and synergetic therapy is a promising therapeutic pattern for antitumor treatment in clinical biology. Here, we innovatively encapsulated graphene quantum dots (GQDs) or methylene blue (MB) together with doxorubicin (DOX) into the cores of poly lactic-co-glycolic acid (PLGA) nanoparticles coated with bovine serum albumin (BSA) based on the emulsion method to synthesize core-shell structure nanoparticles (GQDs@DOX/PB and MB@DOX/PB NPs). The GQDs@DOX/PB NPs exhibited excellent photothermal properties and stability under 808 nm laser irradiation. The in vitro chemophotothermal synergetic experiments manifested that the GQDs@DOX/PB NPs effectively cause the thermal ablation of tumor cells under NIR laser irradiation. Meanwhile, the in vitro chemophotodynamic synergetic experiments revealed that the MB@DOX/PB NPs could produce reactive oxygen species and showed outstanding antitumor efficacy under 660 nm laser irradiation. Consequently, the pH-responsive multifunctional nanoparticles prepared by a facile strategy have a high tumor cell-killing efficacy, manifesting excellent potential in synergistic therapy.

中文翻译：

装载多柔比星和石墨烯量子点/亚甲蓝的多功能纳米平台，用于药物输送和化学光热/光动力协同癌症治疗

用于纳米药物递送和协同治疗的多功能平台是临床生物学中抗肿瘤治疗的有希望的治疗模式。在这里，我们创新地将石墨烯量子点 (GQDs) 或亚甲蓝 (MB) 与阿霉素 (DOX) 一起封装到基于乳液的涂有牛血清白蛋白 (BSA) 的聚乳酸-乙醇酸 (PLGA) 纳米粒子的核心中合成核壳结构纳米粒子（GQDs@DOX/PB 和 MB@DOX/PB NPs）的方法。GQDs@DOX/PB NPs 在 808 nm 激光照射下表现出优异的光热性能和稳定性。体外化学光热协同实验表明，GQDs@DOX/PB NPs在近红外激光照射下有效地引起肿瘤细胞的热消融。同时，体外化学光动力学协同实验表明，MB@DOX/PB NPs可以产生活性氧，并在660 nm激光照射下表现出出色的抗肿瘤功效。因此，通过简便的策略制备的pH响应性多功能纳米粒子具有很高的肿瘤细胞杀伤功效，在协同治疗中表现出优异的潜力。

更新日期：2020-09-04

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