Abstract

The synthesis of 4 new Schiff base based ternary metal (II) complexes from taurine and (1,7-bis(4-hydroxy-3-methoxy phenyl)-1,6-heptadiene-3,5-dione) in liquid state is reported herein. The as synthesized metal complexes of nickel, copper, cobalt, and zinc were characterized by spectrum-analytical techniques like proton nuclear magnetic resonance (1H NMR), Fourier transform infrared spectroscopy (FTIR), electron paramagnetic resonance (EPR), and UV-Visible spectroscopy (UV–Vis). The magnetic moment and molar conductivity measurements were also analyzed. DNA interaction of Cu(II), Ni (II), Zn(II), and Co(II) complexes were investigated by means of absorption titration, cyclic voltammetry (CV), and viscosity analysis. These metal complexes demonstrated good results of interaction with calf thymus (CT) with DNA (via intercalation mode). The synthesized metal complexes and the ligands were screened for antimicrobial activity (in vitro) against the bacterial and fungal species such as Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli by well diffusion method.

摘要

从液态牛磺酸和（1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮）合成4种新型席夫碱三元金属（II）配合物是在此报道。用质子核磁共振 (1H NMR)、傅里叶变换红外光谱 (FTIR)、电子顺磁共振 (EPR) 和紫外-可见光谱等光谱分析技术对合成的镍、铜、钴和锌金属配合物进行表征光谱（UV-Vis）。还分析了磁矩和摩尔电导率测量值。通过吸收滴定、循环伏安法 (CV) 和粘度分析，研究了 Cu(II)、Ni (II)、Zn(II) 和 Co(II) 配合物的 DNA 相互作用。这些金属配合物显示出与小牛胸腺 (CT) 与 DNA（通过嵌入模式）相互作用的良好结果。金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌和大肠埃希菌通过井扩散法。