Objective

To investigate effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected male patients.

Methods

This prospective cohort study included 221 consecutive male patients (>18 years old) with laboratory confirmed SARS-CoV-2 who had been hospitalized due to COVID-19. The patients were divided into 3 groups: Asymptomatic patients (n: 46), symptomatic patients who were hospitalized in the internal medicine unit (IMU) (n: 129), and patients who were hospitalized in the intensive care unit (ICU) (n: 46).

Results

As serum total testosterone level at baseline decreases, probability (%) to be in the ICU significantly increases (p = 0.001). As serum total testosterone level at baseline decreases, probability (%) of mortality significantly increases (p = 0.002). In the patients who had pre-COVID-19 serum gonadal hormones test (n: 24), serum total testosterone level significantly decreased from pre-COVID-19 level of 458 ± 198 ng/dl to 315 ± 120 ng/ml at the time of COVID-19 in the patients (p = 0.003).

Conclusions

COVID-19 might deteriorate serum testosterone level in SARS-CoV-2 infected male patients. Low serum total testosterone level at baseline has a significant increased risk for the ICU and mortality in patients with COVID-19.

中文翻译：

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血清总睾酮及其与其他实验室参数对 SARS-CoV-2 感染男性患者 2019 年冠状病毒病 (COVID-19) 预后的影响：一项队列研究。

客观的

研究血清总睾酮及其与其他实验室参数对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染男性患者 2019 年冠状病毒病 (COVID-19) 预后的影响。

方法

这项前瞻性队列研究包括 221 名连续男性患者（>18 岁），实验室确诊为 SARS-CoV-2，他们因 COVID-19 而住院。将患者分为 3 组：无症状患者（n：46）、住院内科病房（IMU）有症状患者（n：129）和住院重症监护病房（ICU）患者（n : 46)。

结果

随着基线时血清总睾酮水平降低，进入 ICU 的概率 (%) 显着增加 ( p  = 0.001)。随着基线时血清总睾酮水平降低，死亡率的概率 (%) 显着增加 ( p  = 0.002)。在接受 COVID-19 前血清性腺激素测试的患者（n：24）中，血清总睾酮水平从 COVID-19 前的 458 ± 198 ng/dl 显着下降至当时的 315 ± 120 ng/ml患者中的 COVID-19 ( p  = 0.003)。

结论

COVID-19 可能会降低感染 SARS-CoV-2 的男性患者的血清睾酮水平。基线时血清总睾酮水平低会显着增加 COVID-19 患者 ICU 和死亡率的风险。