ABSTRACT

Introduction

Lyotropic liquid crystals (LLCs) are organized mesophases with intermediate properties between liquids and solids. The LLC and its liquid crystalline nanoparticles (LCNPs) have attracted great interest from the scientific community in recent years as potential drug delivery systems due to the high internal ordering and symmetry with a wide interfacial area.

Areas covered

This article aims to gather information and to provide a description of the highly organized structures of LLCs. Updates on production methods and new insights for LCNPs optimization and physico-chemical and morphological caracterization techniques were discussed. We also discussed why these systems proved to be a platform for the design of nanocarrier drug delivery, with an emphasis on topical and transdermal applications.

Expert opinion

Drug delivery platforms are of particular importance to improve the biopharmaceutical aspects of therapies topically. Although several systems can be used, LLC or LCNPs appear to be favored due to their similarity to the lipid structure of the skin. The highly ordered structure and the possibility of chemical modifications make it possible to obtain better clinical responses. The results of several studies support the innovations in this field and predict that these systems can innovate the market of technologies for the treatment of cutaneous diseases and cosmetology.

中文翻译：

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用于皮肤药物递送的溶致液晶系统的进展。

摘要

介绍

溶致液晶（LLC）是中间相，在液体和固体之间具有中间性质。由于具有高度的内部有序性和对称性以及宽的界面面积，LLC及其液晶纳米颗粒（LCNP）近年来已成为潜在的药物输送系统，引起了科学界的极大兴趣。

覆盖区域

本文旨在收集信息并提供对LLCs高度组织化结构的描述。讨论了生产方法的更新以及LCNP优化，理化和形态特征化技术的新见解。我们还讨论了为什么这些系统被证明是设计纳米载体药物递送的平台，重点是局部和透皮应用。

专家意见

药物递送平台对于局部改善疗法的生物药物方面特别重要。尽管可以使用几种系统，但由于LLC或LCNP与皮肤脂质结构的相似性，它们似乎受到青睐。高度有序的结构和化学修饰的可能性使获得更好的临床反应成为可能。多项研究的结果支持了该领域的创新，并预测这些系统可以革新皮肤疾病和美容学治疗技术的市场。