We studied the accuracy of graded exercise testing (GXT) to assess improvements in maximal oxygen uptake (VO_2MAX) with exercise training in unfit individuals with metabolic syndrome (MetS). Forty-four adults with MetS (58±7 years; 36% women; BMI 31.8±4.8 kg·m^-2) underwent 4 months of supervised high-intensity interval exercise training. VO_2MAX was assessed using GXT followed by a constant-load verification test (VerT) at 110% of the maximal work-rate achieved during GXT. VO₂ data from GXT and VerT were compared using repeated measures ANOVA. The mean improvement in VO_2MAX following exercise training was similar when using GXT only or VerT. However, before training, 18 subjects achieved a higher VO_2MAX during the verification test that was (+159 mLO₂·min^-1) higher than the GXT (P<0.001). After training, the underestimation of VO_2MAX by GXT was reduced but still present (+64 mLO₂·min^-1). As a result, improvements in VO_2MAX following exercise training as assessed using GXT only almost doubled the "real" increase in VO_2MAX as measured by VerT in these 18 individuals. In the remaining 26 subjects, GXT scored below VerT only after training (+54 mLO₂·min^-1; P=0.046). As a consequence, GXT underestimated the actual VO_2MAX increases (-49 mLO₂·min^-1; P=0.013) in these individuals. Assessment of changes in VO_2MAX following exercise training using only GXT over-or-underestimates VO_2MAX gains in unfit individuals with MetS. Thus, a verification test may be required to 1) identify the highest VO_2MAX during a maximal exercise test on a cycle ergometer, 2) accurately quantify the true changes in cardiorespiratory fitness following exercise training in unfit individuals with MetS.

中文翻译：

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在不适合患有代谢综合征的个体中进行运动训练后，使用分级运动测试可能不足以量化VO2max的真实变化。

我们研究了分级运动测试（GXT）的准确性，以评估患有代谢综合征（MetS）的不合适个体进行运动训练时最大摄氧量（VO _2MAX）的改善。四十四名成年人（58±7岁；女性36％； BMI 31.8±4.8 kg·m ^-2）接受了为期4个月的高强度间歇运动训练。使用GXT进行VO _2MAX评估，然后进行恒定负载验证测试（VerT），该测试为GXT期间达到的最大工作率的110％。使用重复测量方差分析比较来自GXT和VerT的VO ₂数据。仅使用GXT或VerT时，运动训练后VO _2MAX的平均改善相似。但是，在训练之前，有18位受试者的VO较高验证测试期间的_2MAX高于GXT（+159 mLO ₂ ·min ^-1）（P <0.001）。训练后，GXT对VO _2MAX的低估有所降低，但仍然存在（+64 mLO ₂ ·min ^-1）。结果，使用GXT评估运动训练后VO _2MAX的改善仅使这18个人的Ver 2测量的VO _2MAX “实际”增加几乎翻了一番。在其余26名受试者中，仅在训练后GXT得分低于VerT（+54 mLO ₂ ·min ^-1； P = 0.046）。结果，GXT低估了实际VO _2MAX的增加（-49 mLO ₂·min ^-1；P = 0.013）。仅使用GXT评估运动训练后VO _2MAX的变化即可_高估或低估患有MetS的不适应个体的VO _2MAX增幅。因此，可能需要进行验证测试，以：1）在自行车测功机上进行的最大运动测试期间确定最高的VO _2MAX； 2）在不适合患有MetS的个体中进行运动训练后，准确地量化心肺健康的真实变化。