Synlett ( IF 1.7 ) Pub Date : 2020-09-03 , DOI: 10.1055/s-0040-1707261 M. Manuel B. Marques 1 , A. Sofia Santos
Abstract
Herein we report the use of a soluble polymer support PEG-2000 on Pd-catalyzed reactions to improve the functionalization of aromatic amines and the synthesis of N-heterocycles. Compatibility of metal-catalyzed reactions for assembling privileged structures such as functionalized anilines were studied. PEG-supported anilines were found to be suitable substrates for Pd-catalyzed N-arylation, Sonogashira and Heck reactions. PEGylated substrates were prepared in yields up to 94%. This work consists on a proof of concept on the use of PEGylated anilines on Pd-catalyzed cross-coupling reactions. Indole core was attained in 82% and 62% yields, via two different routes.
Publication History
Received: 21 May 2020
Accepted after revision: 28 July 2020
Publication Date:
03 September 2020 (online)
© 2020. Thieme. All rights reserved
Georg Thieme Verlag KG
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中文翻译:
Pd催化的可溶性聚合物载体上的芳胺功能化
摘要
本文中我们报道了在Pd催化的反应中使用可溶性聚合物载体PEG-2000来改善芳族胺的功能化和N杂环的合成。研究了金属催化反应用于组装特殊结构(如功能化苯胺)的相容性。发现PEG负载的苯胺是Pd催化的N-芳基化,Sonogashira和Heck反应的合适底物。制备聚乙二醇化底物的产率高达94%。这项工作基于在Pd催化的交叉偶联反应中使用PEG化苯胺的概念验证。通过两种不同的途径,吲哚核的收率分别为82%和62%。
出版历史
收到:2020年5月21日
修订后接受:2020年7月28日
发布日期:
2020年9月3日(在线)
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Georg Thieme Verlag
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