Macrophages in the pancreas: Villains by circumstances, not necessarily by actions.,Immunity, Inflammation and Disease

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Macrophages in the pancreas: Villains by circumstances, not necessarily by actions.
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-09-03 , DOI: 10.1002/iid3.345
Andrea F Cruz ₁ , Rokhsareh Rohban ₂ , Farzad Esni _{1,

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Affiliation

Mounting evidence suggest that macrophages play crucial roles in disease and tissue regeneration. However, despite much efforts during the past decade, our knowledge about the extent of macrophages' contribution to adult pancreatic regeneration after injury or during pancreatic disease progression is still limited. Nevertheless, it is generally accepted that some macrophage features that normally would contribute to healing and regeneration may be detrimental in pancreatic cancer. Altogether, the current literature contains conflicting reports on whether macrophages act as friends or foe in these conditions.

中文翻译：

胰腺中的巨噬细胞：环境下的恶棍，不一定是行为。

越来越多的证据表明巨噬细胞在疾病和组织再生中起着至关重要的作用。然而，尽管在过去十年中做出了很多努力，但我们对巨噬细胞在损伤后或胰腺疾病进展过程中对成人胰腺再生的贡献程度的了解仍然有限。然而，人们普遍认为，一些通常有助于愈合和再生的巨噬细胞特征可能对胰腺癌有害。总之，目前的文献中关于巨噬细胞在这些情况下是朋友还是敌人的报道相互矛盾。

更新日期：2020-11-12

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