Regulation of the Central Dogma through Bioinorganic Events with Metal Coordination for Specific Interactions,Bulletin of the Korean Chemical Society

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Regulation of the Central Dogma through Bioinorganic Events with Metal Coordination for Specific Interactions
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-09-03 , DOI: 10.1002/bkcs.12090
Chungwoon Yoon ₁ , Dong‐Heon Lee ₁ , Seung Jae Lee ₁

Affiliation

The central dogma is the core aspect of biological system regulation, receiving much attention from the field of biological chemistry. One of the main regulators of transcription and translation processes is the zinc finger (ZF) proteins, one or more domains of which coordinate with a zinc ion to interact with their binding partner. ZFs are modular domains that function independently in the presence of Zn²⁺ through the generation of short secondary structures via zinc ion coordination, which generate hydrogen bonds, despite being considered structural domains. In this review, structural and functional characteristics of ZF domains will be presented from the perspective of inorganic biochemistry. The major role of ZF domains in the central dogma involves transcriptional regulation through interactions with DNA and translational regulation through the generation of complexes with RNA. These findings indicate that the triggering many biological events can be explained by the coordination and biophysical chemistry of ZFs.

中文翻译：

通过生物无机事件与特定相互作用的金属配合来调节中央教条。

中心教条是生物系统调节的核心方面，受到了生物化学领域的广泛关注。转录和翻译过程的主要调节剂之一是锌指（ZF）蛋白，其一个或多个域与锌离子协同作用以与其结合伴侣相互作用。ZF是在Zn ²⁺存在下独立起作用的模块化结构域通过锌离子配位产生短的二级结构，尽管被认为是结构域，但仍会产生氢键。在这篇综述中，将从无机生物化学的角度介绍ZF域的结构和功能特征。ZF结构域在中央教条中的主要作用包括通过与DNA相互作用进行转录调控，以及通过与RNA形成复合物进行翻译调控。这些发现表明，ZF的配位和生物物理化学可以解释许多生物事件的触发。

更新日期：2020-09-20

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