Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins,The FEBS Journal

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Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-09-03 , DOI: 10.1111/febs.15547
Eli Arama ₁ , Luis Alberto Baena-Lopez ₂ , Howard O Fearnhead ₃

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Apoptosis is a major form of programmed cell death (PCD) that eliminates unnecessary and potentially dangerous cells in all metazoan organisms, thus ensuring tissue homeostasis and many developmental processes. Accordingly, defects in the activation of the apoptotic pathway often pave the way to disease. After several decades of intensive research, the molecular details controlling the apoptosis program have largely been unraveled, as well as the regulatory mechanisms of caspase activation during apoptosis. Nevertheless, an ever‐growing list of studies is suggesting the essential role of caspases and other apoptotic proteins in ensuring nonlethal cellular functions during normal development, tissue repair, and regeneration. Moreover, if deregulated, these novel nonapoptotic functions can also instigate diseases. The difficulty of identifying and manipulating the caspase‐dependent nonlethal cellular processes (CDPs), as well as the nonlethal functions of other cell death proteins (NLF‐CDPs), meant that CDPs and NLF‐CDPs have been only curiosities within the apoptotic field; however, the recent technical advancements and the latest biological findings are assigning an unanticipated biological significance to these nonapoptotic functions. Here, we summarize the various talks presented in the first international conference fully dedicated to discuss CDPs and NFL‐CDPs and named ‘The Batsheva de Rothschild Seminar on Non‐Apoptotic Roles of Apoptotic Proteins’. The conference was organized between September 22, 2019, and 25, 2019, by Eli Arama (Weizmann Institute of Science), Luis Alberto Baena‐Lopez (University of Oxford), and Howard O. Fearnhead (NUI Galway) at the Weizmann Institute of Science in Israel, and hosted a large international group of researchers.

中文翻译：

来自圣地的非致命信息：第一届关于凋亡蛋白非凋亡作用的国际会议

细胞凋亡是程序性细胞死亡（PCD）的一种主要形式，它消除所有后生动物中不必要的和潜在危险的细胞，从而确保组织稳态和许多发育过程。因此，细胞凋亡途径激活的缺陷常常为疾病铺平道路。经过几十年的深入研究，控制细胞凋亡程序的分子细节以及细胞凋亡过程中 caspase 激活的调节机制已基本被阐明。然而，越来越多的研究表明半胱天冬酶和其他凋亡蛋白在确保正常发育、组织修复和再生过程中的非致命性细胞功能方面发挥着重要作用。此外，如果放松管制，这些新的非凋亡功能也会引发疾病。识别和操作caspase依赖性非致死细胞过程(CDP) 以及其他细胞死亡蛋白(NLF-CDP)的非致死功能的难度意味着 CDP 和 NLF- CDP 一直只是细胞凋亡领域的新奇事物。然而，最近的技术进步和最新的生物学发现为这些非凋亡功能赋予了意想不到的生物学意义。在这里，我们总结了第一届专门讨论 CDP 和 NFL-CDP 的国际会议上提出的各种演讲，该会议名为“Batsheva de Rothschild 关于凋亡蛋白的非凋亡作用研讨会”。该会议于 2019 年 9 月 22 日至 25 日期间由魏茨曼科学研究所的 Eli Arama（魏茨曼科学研究所）、Luis Alberto Baena-Lopez（牛津大学）和 Howard O. Fearnhead（NUI Galway）组织。以色列科学界，并接待了大批国际研究人员。

更新日期：2020-09-03

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