Serum response factor‐cofactor interactions and their implications in disease,The FEBS Journal

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Serum response factor‐cofactor interactions and their implications in disease
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-09-03 , DOI: 10.1111/febs.15544
John Oloche Onuh ₁ , Hongyu Qiu ₁

Affiliation

Serum response factor (SRF), a member of the Mcm1, Agamous, Deficiens, and SRF (MADS) box transcription factor, is widely expressed in all cell types and plays a crucial role in the physiological function and development of diseases. SRF regulates its downstream genes by binding to their CArG DNA box by interacting with various cofactors. However, the underlying mechanisms are not fully understood, therefore attracting increasing research attention due to the importance of this topic. This review's objective is to discuss the new progress in the studies of the molecular mechanisms involved in the activation of SRF and its impacts in physiological and pathological conditions. Notably, we summarized the recent studies on the interaction of SRF with its two main types of cofactors belonging to the myocardin families of transcription factors and the members of the ternary complex factors. The knowledge of these mechanisms will create new opportunities for understanding the dynamics of many traits and disease pathogenesis especially, cardiovascular diseases and cancer that could serve as targets for pharmacological control and treatment of these diseases.

中文翻译：

血清反应因子-辅因子相互作用及其对疾病的影响

血清反应因子（SRF），Mcm1，Agamous，Deficiens和SRF的成员（MADS）盒转录因子在所有细胞类型中广泛表达，在疾病的生理功能和发展中起着至关重要的作用。SRF通过与各种辅助因子相互作用而与其CArG DNA盒结合来调节其下游基因。然而，潜在的机制尚未完全被理解，因此由于该主题的重要性，引起了越来越多的研究关注。这篇综述的目的是讨论有关SRF激活及其对生理和病理状况影响的分子机制研究的新进展。值得注意的是，我们总结了有关SRF与属于转录因子心肌家族和三元复杂因子成员的两种主要辅助因子相互作用的最新研究。

更新日期：2020-09-03

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