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The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-09-04 , DOI: 10.1002/cmdc.202000387 Francisco Washington A Barros-Nepomuceno 1, 2 , Daniel de Araújo Viana 3 , Daniel Pascoalino Pinheiro 2 , Fátima de Cássia Evangelista de Oliveira 2 , Jamile Magalhães Ferreira 1, 4 , Maria Goretti R de Queiroz 4 , Xinghua Ma 5 , Bruno Coêlho Cavalcanti 2 , Claudia Pessoa 2 , Martin G Banwell 5, 6
ChemMedChem ( IF 3.6 ) Pub Date : 2020-09-04 , DOI: 10.1002/cmdc.202000387 Francisco Washington A Barros-Nepomuceno 1, 2 , Daniel de Araújo Viana 3 , Daniel Pascoalino Pinheiro 2 , Fátima de Cássia Evangelista de Oliveira 2 , Jamile Magalhães Ferreira 1, 4 , Maria Goretti R de Queiroz 4 , Xinghua Ma 5 , Bruno Coêlho Cavalcanti 2 , Claudia Pessoa 2 , Martin G Banwell 5, 6
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The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T‐J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including hematological, biochemical, histopathological, genotoxic and clastogenic assays. As a result it was established that this alkaloid has a significant therapeutic window and effectively reduces tumor growth (by 40 % and 79 % at doses of 10 and 20 mg/kg/day, respectively). In this regard it displays similar antitumor activity to the anticancer agent cyclophosphamide and alters animal weight in an analogous manner.
中文翻译：
生物碱 Tambjamine J 对植入肉瘤 180 肿瘤细胞的小鼠的影响。
tambjamines 是一小组双吡咯生物碱，它们共同显示出一系列重要的生物活性，包括抗肿瘤、抗菌和免疫抑制特性。本研究的主要目的是对 tambjamine J (T-J) 进行临床前评估，以确定其体内抗肿瘤作用。为此，将肉瘤 180 细胞移植到小鼠体内，然后使用一系列方案评估标题化合物的影响，包括血液学、生化、组织病理学、基因毒性和致畸性分析。因此，确定这种生物碱具有显着的治疗窗口并有效地减少肿瘤生长（在 10 和 20 毫克/千克/天的剂量下分别减少 40 % 和 79 %）。
更新日期：2020-09-04
中文翻译：
生物碱 Tambjamine J 对植入肉瘤 180 肿瘤细胞的小鼠的影响。
tambjamines 是一小组双吡咯生物碱，它们共同显示出一系列重要的生物活性，包括抗肿瘤、抗菌和免疫抑制特性。本研究的主要目的是对 tambjamine J (T-J) 进行临床前评估，以确定其体内抗肿瘤作用。为此，将肉瘤 180 细胞移植到小鼠体内，然后使用一系列方案评估标题化合物的影响，包括血液学、生化、组织病理学、基因毒性和致畸性分析。因此，确定这种生物碱具有显着的治疗窗口并有效地减少肿瘤生长（在 10 和 20 毫克/千克/天的剂量下分别减少 40 % 和 79 %）。
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