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Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-09-04 , DOI: 10.1002/cmdc.202000612 Robert G Carden 1 , Kyle J Sommers 1 , Cassandra L Schrank 2 , Austin J Leitgeb 1 , Javier A Feliciano 1 , William M Wuest 2 , Kevin P C Minbiole 1
ChemMedChem ( IF 3.6 ) Pub Date : 2020-09-04 , DOI: 10.1002/cmdc.202000612 Robert G Carden 1 , Kyle J Sommers 1 , Cassandra L Schrank 2 , Austin J Leitgeb 1 , Javier A Feliciano 1 , William M Wuest 2 , Kevin P C Minbiole 1
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The prevalence of quaternary ammonium compounds (QACs) as common disinfecting agents for the past century has led bacteria to develop resistance to such compounds. Given the alarming increase in resistant strains, new strategies are required to combat this rise in resistance. Recent efforts to probe and combat bacterial resistance have focused on studies of multiQACs. Relatively unexplored, however, have been changes to the primary atom bearing positive charge in these antiseptics. Here we review the current state of the field of both phosphonium and sulfonium amphiphilic antiseptics, both of which hold promise as novel means to address bacterial resistance.
中文翻译：
非氮基两亲性抗菌剂克服致病细菌耐药性的开发进展。
上个世纪，季铵化合物（QAC）作为常用消毒剂的流行导致细菌对此类化合物产生了抗药性。鉴于耐药菌株的惊人增加，需要新的策略来应对耐药性的增加。最近探索和对抗细菌耐药性的努力主要集中在 multiQAC 的研究上。然而，相对而言，这些防腐剂中带正电荷的基本原子的变化尚未被探索。在这里，我们回顾了鏻和锍两亲性防腐剂领域的现状，这两种防腐剂都有望成为解决细菌耐药性的新方法。
更新日期：2020-11-06
中文翻译：
非氮基两亲性抗菌剂克服致病细菌耐药性的开发进展。
上个世纪，季铵化合物（QAC）作为常用消毒剂的流行导致细菌对此类化合物产生了抗药性。鉴于耐药菌株的惊人增加，需要新的策略来应对耐药性的增加。最近探索和对抗细菌耐药性的努力主要集中在 multiQAC 的研究上。然而，相对而言，这些防腐剂中带正电荷的基本原子的变化尚未被探索。在这里，我们回顾了鏻和锍两亲性防腐剂领域的现状，这两种防腐剂都有望成为解决细菌耐药性的新方法。
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