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Mechanics as a Means of Information Propagation in Development.
BioEssays ( IF 3.2 ) Pub Date : 2020-09-03 , DOI: 10.1002/bies.202000121 Miriam A Genuth 1 , Scott A Holley 1
BioEssays ( IF 3.2 ) Pub Date : 2020-09-03 , DOI: 10.1002/bies.202000121 Miriam A Genuth 1 , Scott A Holley 1
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New research demonstrates that mechanics can serve as a means of information propagation in developing embryos. Historically, the study of embryonic development has had a dichotomy between morphogens and pattern formation on the one hand and morphogenesis and mechanics on the other. Secreted signals are the preeminent means of information propagation between cells and used to control cell fate, while physical forces act downstream or in parallel to shape tissue morphogenesis. However, recent work has blurred this division of function by demonstrating that mechanics can serve as a means of information propagation. Adhesive or repulsive interactions can propagate through a tissue as a wave. These waves are rapid and directional and can be used to control the flux of cells through a developmental trajectory. Here, two examples are reviewed in which mechanics both guides and mediates morphogenesis and two examples in which mechanics intertwines with morphogens to regulate cell fate.
中文翻译：
力学作为发展中信息传播的手段。
新的研究表明，力学可以作为发育胚胎中信息传播的手段。从历史上看，胚胎发育的研究一直存在二分法：一方面是形态发生素和模式形成，另一方面是形态发生和力学。分泌信号是细胞之间信息传播的重要手段，用于控制细胞命运，而物理力则作用于下游或平行于塑造组织形态发生。然而，最近的工作通过证明力学可以作为信息传播的手段，模糊了这种功能的划分。粘附或排斥相互作用可以作为波在组织中传播。这些波快速且有方向性，可用于控制细胞在发育轨迹上的流动。在这里，我们回顾了两个例子，其中力学指导和介导形态发生，以及两个例子，其中力学与形态发生素交织在一起调节细胞命运。
更新日期：2020-10-22
中文翻译：
力学作为发展中信息传播的手段。
新的研究表明，力学可以作为发育胚胎中信息传播的手段。从历史上看，胚胎发育的研究一直存在二分法：一方面是形态发生素和模式形成，另一方面是形态发生和力学。分泌信号是细胞之间信息传播的重要手段，用于控制细胞命运，而物理力则作用于下游或平行于塑造组织形态发生。然而，最近的工作通过证明力学可以作为信息传播的手段，模糊了这种功能的划分。粘附或排斥相互作用可以作为波在组织中传播。这些波快速且有方向性，可用于控制细胞在发育轨迹上的流动。在这里，我们回顾了两个例子，其中力学指导和介导形态发生，以及两个例子，其中力学与形态发生素交织在一起调节细胞命运。
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