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COVID-19-related disease severity in pregnancy.
American Journal of Reproductive Immunology ( IF 2.5 ) Pub Date : 2020-09-03 , DOI: 10.1111/aji.13339
Jennifer L Thompson 1 , Lynsa M Nguyen 1 , Kristen N Noble 2 , David M Aronoff 3, 4, 5
Affiliation  

The pandemic caused by COVID‐19 is affecting populations and healthcare systems worldwide. As we gain experience managing COVID‐19, more data become available on disease severity, course, and treatment in patients infected with the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). However, data in pregnancy remain limited. This narrative review of COVID‐19 during pregnancy underscores key knowledge gaps in our understanding of the impact of this viral infection on reproductive health. Current data suggest that pregnant people have similar disease course and outcomes compared to nonpregnant people, with the majority experiencing mild disease; however, pregnant people may have increased risk of hospitalization and intensive care unit (ICU) admission. Among patients who develop severe and critical disease, major maternal morbidity and mortality have been described including cardiomyopathy, mechanical ventilation, extracorporeal membrane oxygenation, and death. Many questions remain regarding maternal severity of disease in COVID‐19. Further research is needed to better understand disease course in pregnancy. Additionally, the inclusion of pregnant patients in therapeutic trials will provide vital data on treatment options for patients. As we continue to treat more patients affected by SARS‐CoV‐2, multidisciplinary care and continued research are both needed to achieve optimal outcomes for mother and fetus.

中文翻译:

妊娠中COVID-19相关疾病的严重程度。

由COVID-19引起的大流行正在影响全世界的人口和医疗保健系统。随着我们获得管理COVID-19的经验,在感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的患者中,可获得有关疾病严重程度,病程和治疗的更多数据。但是,怀孕的数据仍然有限。怀孕期间对COVID-19的叙述性回顾强调了我们对这种病毒感染对生殖健康的影响的理解方面的关键知识差距。目前的数据表明,与未怀孕的人相比,孕妇的病程和结局相似,大多数人患有轻度疾病。但是,孕妇可能会增加住院和重症监护病房(ICU)入院的风险。在发生严重和严重疾病的患者中,已经描述了主要的母亲发病率和死亡率,包括心肌病,机械通气,体外膜氧合和死亡。关于COVID-19中的母亲疾病严重程度,仍然存在许多问题。需要进一步的研究以更好地了解怀孕期间的疾病进程。此外,将怀孕患者纳入治疗试验将为患者提供重要的治疗选择数据。随着我们继续治疗更多受SARS-CoV-2影响的患者,都需要多学科护理和持续研究以实现母婴最佳结局。需要进一步的研究以更好地了解怀孕期间的疾病进程。此外,将怀孕患者纳入治疗试验将为患者提供重要的治疗选择数据。随着我们继续治疗更多受SARS-CoV-2影响的患者,都需要多学科护理和持续研究以实现母婴最佳结局。需要进一步的研究以更好地了解怀孕期间的疾病进程。此外,将怀孕患者纳入治疗试验将为患者提供重要的治疗选择数据。随着我们继续治疗更多受SARS-CoV-2影响的患者,都需要多学科护理和持续研究以实现母婴最佳结局。
更新日期:2020-10-29
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