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Frostbite: Current status and advancements in therapeutics
Journal of Thermal Biology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jtherbio.2020.102716 Kumud Joshi 1 , Danswrang Goyary 2 , Bhaskar Mazumder 3 , Pronobesh Chattopadhyay 2 , Reshmi Chakraborty 2 , Y D Bhutia 2 , Sanjeev Karmakar 2 , Sanjai Kumar Dwivedi 2
Journal of Thermal Biology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jtherbio.2020.102716 Kumud Joshi 1 , Danswrang Goyary 2 , Bhaskar Mazumder 3 , Pronobesh Chattopadhyay 2 , Reshmi Chakraborty 2 , Y D Bhutia 2 , Sanjeev Karmakar 2 , Sanjai Kumar Dwivedi 2
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Frostbite is a severe ischemic injury which occurs due to the tissue vascular damage after sub-zero temperature tissue exposure. Deep frostbite can result in necrosis and may need amputation of affected tissue. Though a serious injury, it is not very well understood, and further scientific exploration is needed. This work explores the current understanding of the pathophysiology of frostbite. We reviewed the current status of the diagnostics, the drugs, the therapies and the surgical practices for prevention and management of frostbite. Advances in nanotechnology and drug delivery had improved the therapeutic outcomes significantly. This review also explored the latest advancements and researches done for development of newer therapeutics and diagnostics for frostbite care.
中文翻译：
冻伤：治疗的现状和进展
冻伤是一种严重的缺血性损伤，是由于组织血管在低于零温度的温度下受到损伤而发生的。深度冻伤会导致坏死，可能需要截肢受影响的组织。虽然是重伤，但还不是很清楚，还需要进一步的科学探索。这项工作探索了目前对冻伤病理生理学的理解。我们回顾了预防和管理冻伤的诊断、药物、疗法和外科手术的现状。纳米技术和药物输送的进步显着改善了治疗效果。本综述还探讨了为开发用于冻伤护理的新疗法和诊断方法而进行的最新进展和研究。
更新日期：2020-10-01
中文翻译：
冻伤：治疗的现状和进展
冻伤是一种严重的缺血性损伤，是由于组织血管在低于零温度的温度下受到损伤而发生的。深度冻伤会导致坏死，可能需要截肢受影响的组织。虽然是重伤，但还不是很清楚，还需要进一步的科学探索。这项工作探索了目前对冻伤病理生理学的理解。我们回顾了预防和管理冻伤的诊断、药物、疗法和外科手术的现状。纳米技术和药物输送的进步显着改善了治疗效果。本综述还探讨了为开发用于冻伤护理的新疗法和诊断方法而进行的最新进展和研究。
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