The procalcitonin (PCT) assay is FDA-approved to help guide antimicrobial treatment, however, conflicting data exist regarding its impact on durations of therapy. The purpose of this study was to compare the impact of PCT to a targeted audit-and-feedback (TAF) strategy on antibiotic durations of therapy for community-acquired pneumonia (CAP). A retrospective cohort study was conducted at two community teaching hospitals, one implementing PCT with routine audit-and-feedback and one implementing TAF recommending 5 days of therapy for uncomplicated CAP. Three hundred eleven patients with antibiotics ordered having an indication of pneumonia were included (Pre-TAF n = 80, Pre-PCT n = 80, Post-TAF n = 80, Post-PCT n = 71). Average duration of therapy was similar at baseline (Pre-TAF = 7.0 days vs Pre-PCT = 7.8 days, p = 0.1) and post-intervention (Post-TAF = 5.5 days vs Post-PCT = 5.4 days, p = 0.8) between groups. PCT and TAF were equally effective antimicrobial stewardship strategies in reducing total days of antibiotic therapy prescribed for CAP with no differences observed in patient outcomes.

降钙素原（PCT）测定法已获得FDA批准，可帮助指导抗微生物治疗，但有关其对治疗持续时间的影响，存在相互矛盾的数据。这项研究的目的是比较PCT与针对社区获得性肺炎（CAP）抗生素治疗持续时间的有针对性的审核和反馈（TAF）策略的影响。在两家社区教学医院进行了一项回顾性队列研究，其中一家实施PCT，并进行例行审核和反馈，另一家实施TAF，建议对无并发症的CAP进行5天的治疗。三百11名患者用抗生素有序具有被包括肺炎的指示（预TAF Ñ  = 80，预PCT Ñ  = 80，后TAF Ñ  = 80，后PCT Ñ = 71）。在基线时（TAF前= 7.0天，PCT前= 7.8天，p = 0.1）和干预后（TAF后= 5.5天，PCT后= 5.4天，p = 0.8），平均治疗时间相似。组之间。PCT和TAF是减少CAP抗生素治疗总天数的同样有效的抗菌药物管理策略，患者预后无差异。