Abstract A novel Co(II)-based metal-organic framework (MOF) {[Co 2 (TCPP)(BPY)](DMF) 3 } n ( 1 ) with a pillared structure based on 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H 4 TCPP) and 4,4′-bipyridine (BPY) is designed and synthesized via the solvothermal reaction. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano- 1 hereafter). After the construction of the acute cerebral infarction animal model, the infarct area of the brain is measured after 2 weeks of treatment with the compound. Then, ELISA is performed to detect the content of hs-CRP and IL-1β and TNF-α in the serum.

中文翻译：

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一种新的三维 Co(II)-混合配体 MOF：通过减少 HS-CRP 含量和炎症反应对急性脑梗死的保护作用

摘要 一种新型的基于 Co(II) 的金属有机骨架 (MOF) {[Co 2 (TCPP)(BPY)](DMF) 3 } n ( 1 ) 基于 2,3,5,6-通过溶剂热反应设计并合成了四（4-羧基苯基）吡嗪（H 4 TCPP）和4,4'-联吡啶（BPY）。此外，实施了生手研磨技术以减小复合物1的粒径以产生纳米级1（以下表示为nano-1）。急性脑梗塞动物模型建立后，用化合物治疗2周后测量脑梗塞面积。然后进行ELISA检测血清中hs-CRP、IL-1β和TNF-α的含量。