New heterocycle compound 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene (1), designed using 5-iodo-2-methylbenzoic acid (2) as the starting material is successfully obtained via the multiple synthesis route and finally characterized by IR, 1H NMR, and single crystal X-ray crystallography. In addition, the in vitro anticancer activity of compound 1 on three human lung cancer cells (H20, H2227, and H69) is further determined, which suggests that compound 1 may be a potential anticancer agent.

中文翻译：

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2-(4-氟苯基)-5-(5-碘-2-甲基苄基)噻吩的合成、晶体结构、抗肺癌活性

以5-碘-2-甲基苯甲酸(2)为起始原料设计的新型杂环化合物2-(4-氟苯基)-5-(5-碘-2-甲基苄基)噻吩(1)合成路线，最后通过IR、1H NMR和单晶X射线晶体学表征。此外，进一步确定了化合物1对三种人肺癌细胞（H20、H2227和H69）的体外抗癌活性，这表明化合物1可能是一种潜在的抗癌剂。