Abstract New heterocyclic compound (S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran ( 1 ), designed by utilizing 5-bromo-2-chlorobenzoic acid ( 2 ) as the starting material, is obtained by the organic synthesis and then characterized by single crystal X-ray crystallography, 1 H NMR and IR spectroscopy. In the biological study, the CCK-8 assay is performed to evaluate the inhibitory effect of the compound on SPC-A-1 human lung adenocarcinoma cells in vitro by measuring the cancer cell viability. Then, the anticancer activity of the compound is also confirmed by the in vivo xenograft experiment by measuring the mice body weight and the cancer volume.

中文翻译：

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一种新的杂环化合物：晶体结构和抗人肺腺癌细胞的抗癌活性

摘要 以5-溴-2-氯苯甲酸( 2 )为起始原料设计的新型杂环化合物(S)-3-(4-(5-溴-2-氯苄基)苯氧基)四氢呋喃( 1 )由有机合成，然后通过单晶X射线晶体学、 1 H NMR和IR光谱表征。生物学研究中，通过CCK-8实验，通过测定癌细胞活力，评价化合物对SPC-A-1人肺腺癌细胞的体外抑制作用。然后，通过测量小鼠体重和癌症体积，通过体内异种移植实验也证实了该化合物的抗癌活性。