Abstract A bimetallic coordination polymer is prepared via a hydrothermal reaction of H 2 DDBA and In(NO 3 ) water with NaOH as a pH regulator. Its chemical formula is [In 2 Na(H 2 O) 6 (ddba) 3 ](NO 3 )(H 2 O) 7 ( 1 , H 2 ddba = 4,4′-dithiodibenzoic acid). The composition and atomic arrangement of the prepared complexes are studied by the elemental analysis (EA) and the thermogravimetric analysis (TGA), powder and single crystal X-ray diffraction measurements. Moreover, a process of sonochemistry with oleic acid treatment at 453 K is used to produce nanostructure the biological function detection, a miRNA relative expression is detected via RT-PCR and Bcl-2 expression level is determined with the Western blot. The Annexin V-FITC/PI staining is performed to detect retinoblastoma cell apoptosis after treatment with nano- 1 .

中文翻译：

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基于柔性 4,4'-二硫代二苯甲酸的 In(III)-Na(I) 配位聚合物的晶体结构和抗癌活性

摘要 通过H 2 DDBA 和In(NO 3 ) 水与NaOH 作为pH 调节剂的水热反应制备双金属配位聚合物。其化学式为[In 2 Na(H 2 O) 6 (ddba) 3 ](NO 3 )(H 2 O) 7 ( 1 , H 2 ddba = 4,4'-二硫代二苯甲酸)。通过元素分析 (EA) 和热重分析 (TGA)、粉末和单晶 X 射线衍射测量来研究制备的配合物的组成和原子排列。此外，采用453 K油酸处理的声化学过程产生纳米结构生物功能检测，通过RT-PCR检测miRNA相对表达，用Western印迹确定Bcl-2表达水平。进行Annexin V-FITC/PI染色以检测用nano-1处理后的视网膜母细胞瘤细胞凋亡。