Background: Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive review of the literature. Patients and Methods: We report a case of a 23-year-old female with a mass located in the posterior neck and the upper back and a case of a 50-year-old male with a mass located in the posterior neck, which were proved to be nuchal-type fibromas in the histopathological examination. We also searched the PubMed/Medline database for published cases of nuchal-type fibromas. Results and Discussion: Nuchal-type fibroma is a rare benign tumor arising from the connective tissue, usually in the posterior neck, which affects different ages, with most patients being male. It is a poorly circumscribed tumor consisting of hypocellular, thick, dense and haphazardly arranged collagen bundles with entrapped adipocytes, nerve fibers and muscle fascicles and a few scattered spindle cells, which are CD34 positive. Its excision is curative, and the recurrence risk is generally low. However, patients with Gardner's syndrome may experience recurrence more frequently. Conclusion: Nuchal-type fibroma should be included in the differential diagnosis of subcutaneous, soft-tissue masses, especially when these involve the posterior neck.

中文翻译：

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颈项型纤维瘤：单中心经验和系统文献综述

背景：颈项型纤维瘤是一种罕见的起源于结缔组织的良性肿瘤。我们的目的是通过两个这种肿瘤的病例和对文献的全面回顾来展示我们的经验。患者和方法：我们报告了 1 例 23 岁女性肿块位于颈后和上背部和 1 例 50 岁男性肿块位于颈后部的病例。经组织病理学检查证实为颈项型纤维瘤。我们还搜索了 PubMed/Medline 数据库中已发表的颈项型纤维瘤病例。结果与讨论：颈项型纤维瘤是一种少见的起源于结缔组织的良性肿瘤，好发于颈后部，影响不同年龄，以男性居多。它是一种界限不清的肿瘤，由细胞少、厚、密集且随意排列的胶原束，夹杂着脂肪细胞、神经纤维和肌肉束，以及一些散在的梭形细胞，CD34 阳性。其切除可治愈，复发风险普遍较低。然而，加德纳综合征患者可能会更频繁地复发。结论：颈项型纤维瘤应包括在皮下软组织肿块的鉴别诊断中，尤其是当这些肿块涉及后颈部时。