Background/Aim: Urinary obstruction is a condition of impaired urinary drainage, which may result in progressive renal deterioration. This study applied 99mTc-labeled dimercaptosuccinic acid (99mTc-DMSA) renal scintigraphy to a rabbit model of right ureter obstruction and evaluated its utility in studying obstructive renal diseases. Materials and Methods: Complete unilateral ureter obstruction in rabbits was generated by complete ligation of the right ureter. Renal function was investigated during a 4-week post-obstruction period by obtaining planar images of 99mTc-DMSA activity following ear vein injection. Renal blood perfusion was evaluated by non-invasive scintigraphy in conjunction with parallel histological and hematological examinations. Results: Renal perfusion was remarkably and rapidly reduced in the ureter-obstructed kidneys. During the experimental period, the size of left kidney appeared normal in the scintigraphic images, but the ureter-obstructed right kidney progressively became larger. Histopathological examination showed flattening and atrophy of tubules, enlargement of interstitial areas, accumulation of extracellular martices and infiltration of inflammatory cells in the obstreucted kidney. Conclusion: 99mTc-DMSA scintigraphy is a sensitive, non-invasive method to assess renal function in unilateral kidney diseases.

中文翻译：

---

使用 99mTc-DMSA 评估输尿管梗阻模型的肾功能

背景/目的：尿路梗阻是一种尿路引流障碍，可能导致肾脏进行性恶化。本研究将 99mTc 标记的二巯基琥珀酸 (99mTc-DMSA) 肾闪烁扫描应用于右输尿管梗阻的兔模型，并评估其在研究阻塞性肾病中的效用。材料和方法：通过完全结扎右侧输尿管产生兔子的完全单侧输尿管阻塞。通过在耳静脉注射后获得 99mTc-DMSA 活性的平面图像，在梗阻后 4 周期间研究肾功能。通过非侵入性闪烁扫描结合平行的组织学和血液学检查来评估肾血灌注。结果：输尿管阻塞肾脏的肾灌注显着且迅速地减少。实验期间，闪烁显像显示左肾大小正常，但输尿管梗阻的右肾逐渐变大。组织病理学检查显示肾小管扁平萎缩，间质区扩大，细胞外基质积聚，炎性细胞浸润。结论：99mTc-DMSA 闪烁扫描是一种灵敏、无创的单侧肾脏疾病肾功能评估方法。阻塞肾中细胞外基质的积累和炎症细胞的浸润。结论：99mTc-DMSA 闪烁扫描是一种灵敏、无创的单侧肾脏疾病肾功能评估方法。阻塞肾中细胞外基质的积累和炎症细胞的浸润。结论：99mTc-DMSA 闪烁扫描是一种灵敏、无创的单侧肾脏疾病肾功能评估方法。