Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. All mice were randomly divided into control, low-dose DMC (30 mg/kg), and high-dose DMC (50 mg/kg) groups and individual mice were treated intraperitoneally accordingly every 2 days. Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. Conclusion: These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future.

中文翻译：

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去甲氧基姜黄素抑制人宫颈癌细胞异种移植瘤的体内生长

背景/目的：去甲氧基姜黄素 (DMC) 是天然植物姜黄素的衍生物，在体外和体内对各种人类癌细胞具有抗肿瘤作用。然而，没有报道披露DMC是否可以影响体内人宫颈癌细胞的生长。因此，我们在本研究中研究了 DMC 对裸鼠 HeLa 细胞异种移植模型的抗肿瘤作用。材料与方法：24只裸鼠皮下注射HeLa细胞。将所有小鼠随机分为对照组、低剂量DMC（30 mg/kg）和高剂量DMC（50 mg/kg）组，每2天对单个小鼠进行相应的腹腔注射。结果：DMC 显着降低了小鼠 HeLa 细胞异种移植物的肿瘤重量和体积，表明异种移植物肿瘤的生长受到抑制。结论：