Aim: To elucidate the common and different points between sarcopenia and frailty in chronic liver damage (CLD). Patients and Methods: Patients with both grip strength decline and skeletal muscle index decline were regarded as sarcopenia. Frailty was defined as a syndrome in which 3 or more of the following criteria were met: i) exhaustion, ii) body weight loss, iii) slow walking speed, iv) muscle weakness, and v) low physical activity. Results: Sarcopenia and frailty were identified in 52 patients (15.2%) and 46 (13.5%), respectively. The prevalence of sarcopenia and frailty was well stratified according to age and the liver cirrhosis (LC) status. In the multivariate analysis, we identified significant factors for sarcopenia: i) age, ii) LC, iii) body mass index and iv) extracellular water (ECW) to total body water (TBW) ratio, while only the ECW to TBW ratio was significant for frailty. Conclusion: Sarcopenia and frailty in CLD should be separately evaluated.

中文翻译：

---

慢性肝损伤中的肌肉减少症和虚弱：共同点和不同点

目的：阐明慢性肝损伤（CLD）中肌肉减少症和虚弱之间的共同点和不同点。患者和方法： 握力下降和骨骼肌指数下降的患者被认为是肌肉减少症。虚弱被定义为满足以下 3 个或更多标准的综合征：i) 疲惫，ii) 体重减轻，iii) 步行速度缓慢，iv) 肌肉无力，以及 v) 体力活动不足。结果：分别在 52 名患者 (15.2%) 和 46 名 (13.5%) 中发现肌肉减少症和虚弱。肌肉减少症和虚弱的患病率根据年龄和肝硬化 (LC) 状态进行了很好的分层。在多变量分析中，我们确定了肌肉减少症的重要因素：i) 年龄，ii) LC，iii) 体重指数和 iv) 细胞外水 (ECW) 与全身水分 (TBW) 的比率，而只有 ECW 与 TBW 的比率对虚弱有显着影响。结论：应分别评估 CLD 中的肌肉减少症和虚弱。