Supramolecular hydrogels from unprotected dipeptides: a comparative study on stereoisomers and structural isomers.,Soft Matter

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Supramolecular hydrogels from unprotected dipeptides: a comparative study on stereoisomers and structural isomers.
Soft Matter ( IF 2.9 ) Pub Date : 2020-09-03 , DOI: 10.1039/d0sm01191f
Ottavia Bellotto ₁ , Slavko Kralj , Rita De Zorzi , Silvano Geremia , Silvia Marchesan

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Amino acid stereoconfiguration has been shown to play a key role in the self-assembly of unprotected tripeptides into hydrogels under physiological conditions. Dramatic changes were noted for hydrophobic sequences based on the diphenylalanine motif from the formation of amorphous aggregates in the case of homochiral peptides to nanostructured and stable hydrogels in the case of heterochiral stereoisomers. Herein, we report that by further shortening the sequence to a dipeptide, the overall differences between isomers are less marked, with both homo- and hetero-chiral dipeptides forming gels, although with different stability over time. The soft materials are studied by a number of spectroscopic and microcopic techniques, and single-crystal X-ray diffraction to unveil the supramolecular interactions of these hydrogel building blocks.

中文翻译：

来自未保护的二肽的超分子水凝胶：立体异构体和结构异构体的比较研究。

已显示氨基酸立体构型在生理条件下在未保护的三肽自组装成水凝胶中起关键作用。注意到基于二苯丙氨酸基序的疏水序列发生了戏剧性的变化，从同手性肽形成无定形聚集体到异手性立体异构体形成纳米结构稳定水凝胶。在本文中，我们报道了通过进一步缩短序列至二肽，异构体之间的总体差异较少，同-手性和杂-手性二肽均形成凝胶，尽管随时间具有不同的稳定性。通过许多光谱学和显微技术以及单晶X射线衍射对软材料进行了研究，以揭示这些水凝胶构件的超分子相互作用。

更新日期：2020-09-16

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