Nickel-catalyzed enantioselective electroreductive cross-couplings,Organic Chemistry Frontiers

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Nickel-catalyzed enantioselective electroreductive cross-couplings
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-09-03 , DOI: 10.1039/d0qo00901f
Zhijun Zhou _{1,

2,

3,

4} , Sheng Xu _{1,

2,

3,

4} , Jing Zhang _{1,

2,

3,

4} , Wangqing Kong _{1,

2,

3,

4}

Affiliation

Ni-Catalyzed reductive cross-coupling of two electrophiles has recently evolved into a powerful means for building diverse carbon–carbon bonds in an enantioselective manner. However, this strategy usually requires the use of excessive metal powder as a reducing agent, which poses severe challenges with respect to reproducibility and sustainability. Electrochemical cathode reduction provides new opportunities for reductive cross-coupling reaction in an environmentally benign manner. In this highlight, we summarize the recent progress in Ni-catalyzed enantioselective electroreductive coupling reactions.

中文翻译：

镍催化的对映选择性电交叉偶联

镍催化的两个亲电试剂的还原性交叉偶联最近已发展成为一种以对映选择性的方式建立各种碳-碳键的有效方法。然而，该策略通常需要使用过量的金属粉末作为还原剂，这在可再现性和可持续性方面提出了严峻的挑战。电化学阴极还原以环境友好的方式为还原性交叉偶联反应提供了新的机会。在这一亮点中，我们总结了镍催化的对映选择性电还原偶联反应的最新进展。

更新日期：2020-10-13

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